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Small ubiquitin-related modifier 1

This gene encodes a protein that is a member of the SUMO small ubiquitin-like modifier protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. Howev ...

SMARCAL1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 is a protein that in humans is encoded by the SMARCAL1 gene.

SMC6

Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene. He is involved in the alternative lengthening of telomeres mechanism of cancer.

SMPD4

Model organisms have been used in the study of SMPD4 function. A conditional knockout mouse line called Smpd4 tm2bKOMPWtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to ...

SNX17

This gene encodes a member of the sorting nexin family. Members of this family contain a phox PX domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region ...

Sodium-calcium exchanger

The sodium-calcium exchanger is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium by allowing Na + to flow down its gradient across the plasma membrane in e ...

Sodium-dependent multivitamin transporter

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene. Its supposed to be the Transporter to the uptake of Biotin and Pantothenic acid in the blood-brain barrier.

SOS1

SOS1 is a guanine nucleotide exchange factor GEF which interacts with RAS proteins to turn GDP into GTP, or from an inactive state to an active state to signal cell proliferation. RAS genes e.g., MIM 190020 encode membrane-bound guanine nucleotid ...

SP110

SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene. Nuclear body is a multiprotein complex that may have a role in transcription regulation. This gene is a member of the SP100 / SP140 family of nuclear body protei ...

Spastin

The human gene SPAST codes for the microtubule-severing protein of the same name, commonly known as spastin. This gene encodes a member Attas AAA associated with various cellular activities family protein. Members of this family of proteins share ...

SPTBN1

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It ...

SRD5A2

3-oxo-5α-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene. It is one of three forms of 5α-reductase. Steroid 5α-reductase catalyzes the conversion of the male hormone testosterone into a more potent androgen, di ...

ST3GAL5

Lactosylceramide alpha-2.3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL5 gene. Ganglioside GM3 is known to participate in induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast mor ...

St6 beta-galactoside alpha-2.6-sialyltransferase 2

This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone respons ...

STAM2

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif ITAM. Similar to ...

STARD7

StAR-related lipid transfer domain protein 7 or gestational trophoblastic tumor gene-1 is a lipid transporter that specifically binds and transports phosphatidylcholine between membranes.

STEAP3

Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene. Metalloreductase STEAP3 is capable of turning the iron from the insoluble ferric iron into soluble ferrous 3 Fe 2 Form. STEAP3 and other cool protein, with the exc ...

Sterolin

ABCG5 and ABCG8 genes encode for two proteins sterolin-1 and -2, respectively. Sterolin-1 and –2 are two half’ adenosine triphosphate binding cassette transporters which found to be indispensable for the regulation of sterol absorption and excret ...

STK39

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene. This gene encodes a serine / threonine kinase that function in the cellular stress response path. Kinases are activated in response t ...

SUCLG1

The enzyme encoded by SUCLG1 can exist in either a phosphorylated form or a dephosphorylated form. In the dephosphorylated structure, a phosphate ion works in coordination with a histidine residue in the active site and the two alpha helices, one ...

SULT1C2

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure nu ...

SULT1C3

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure nu ...

SULT1C4

Sulfotransferase 1C4 is an enzyme that in humans is encoded by the SULT1C4 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. These cytosolic enzymes differ in thei ...

SUPT7L

Model organisms have been used in the study of SUPT7L function. A conditional knockout mouse line, called Supt7l tm1aEUCOMMWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project t ...

Syndecan 1

The protein encoded by this gene is a transmembrane type I heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecan-1 core protein consists of an extracellular domain which can be substituted with heparan sul ...

TAF1B

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein TBP and three TBP-associated factors TAFs specific for RNA polymerase I. This complex, known as SL1, binds to the core promot ...

TANK (gene)

The TRAF tumor necrosis factor receptor-associated factor family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can b ...

Telomere-associated protein RIF1

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene. RIF1 and RIF2 cap the ends of chromosomes telomeres of yeast. In higher eukaryotes, Rif1 is involved in the DNA damage response, organization of chromatin a ...

Tet methylcytosine dioxygenase 3

Members of the ten-eleven translocation TET gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009.

Tetratricopeptide repeat domain 21b

This gene encodes a member of TTC21 family, containing several tetratricopeptide repeat TPR domains. This protein is localized to the cilium axoneme, and may play a role in retrograde intraflagellar transport in cilia. Mutations in this gene are ...

TGF alpha

Transforming growth factor alpha is a protein that in humans is encoded by the TGFA gene. As a member of the epidermal growth factor family, TGF-α is a mitogenic polypeptide. The protein becomes activated when binding to receptors capable of prot ...

Thymosin α1

Thymosin α 1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene. It was the first of peptides from fraction 5 Thymosin to be completely sequenced and synthesized. Unlike β thymosins, to whic ...

TLK1

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.

TMEM18

TMEM18 seems to affect energy levels through insulin and glucagon signaling, and in flies, its downregulation induces a metabolic state resembling type-II diabetes Overexpression of TMEM18 protein increases the migration ability of neural stem ce ...

TMEM131

Transmembrane protein 131 is a protein that is encoded by the TMEM131 gene in humans. The TMEM131 protein contains three domains of unknown function 3651 and two transmembrane domains. This protein has been implicated as having a role in T cell f ...

TMSB10

Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene. TMSB10 is a member of the beta-thymosin are a family of peptides. TMSB10 plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin mo ...

TNS1

Tensin-1 is a protein that in humans is encoded by the TNS1 gene. The protein encoded by this gene is localized to focal adhesions, regions of the plasma membrane when a cell attaches to the matrix. This protein crosslinks actin filaments and con ...

TP53I3

Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene. The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stress and irradiation. This ...

Translin

Translin is a DNA-binding protein that in humans is encoded by the TSN gene. Together with translin-associated factor X, translin forms the component 3 of promoter of RISC complex which facilitates endonucleolytic cleavage of the passenger strand ...

TRIB2

Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene. TRIB2 is a pseudokinase member of the class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro. It is known to signal ...

TSG-6

Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans is encoded by the TNFAIP6 gene.

TSSC1

This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated ...

TUBA4A

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is compo ...

TXNDC9

Thioredoxin domain-containing protein 9 is a protein that in humans is encoded by the TXNDC9 gene. The protein encoded by this gene is a member of the family thioredoxin. The exact function of this protein is not known, but it is associated with ...

UBE2E3

Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene. Modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitinatio ...

UDP glucuronosyltransferase 1 family, polypeptide A1

UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene. UGT-1A is uridinediphosphate glucuronosyltransferase UDP-glucuronosyltransferase, UDPGT, an enzyme of the glucuronidation path that tr ...

UGT1A5

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part ...

UGT1A7 (gene)

UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene. This gene encodes a UDP-glucuronosyltransferase, an enzyme way is glukuronizatia that transforms small lipophilic molecules, such as s ...

UGT1A9

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part ...

UXS1

UDP-glucuronic acid decarboxylase 1 is an enzyme that in humans is encoded by the UXS1 gene. UDP-glucuronate decarboxylase the UGD, EC 4.1.1.35 catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is used to initiate glycosamino ...