ⓘ HNRNPK

                                     

ⓘ HNRNPK

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins hnRNPs. The hnRNPs are RNA-binding proteins, and they complex with heterogeneous nuclear RNA hnRNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.

In hnRNP proteins have distinct nucleic acid binding properties of the acid. The protein encoded by this gene, is in the enlightenment of nucleoplasm and three repeats of Kh domains that binds to RNAS. It differs among other hnRNP proteins in its unconditional preferences, it binds hard sheet. This protein is also believed to a role in the progression of the cell cycle. Several alternative spliced variants of the transcript have been described for this gene, but was described only three choices.

Mutations in both copies of HNRNPK are embryonic lethal in mice. Mice with both copies of the gene knocked out die before the 14th day of embryonic development.