ⓘ Delta-aminolevulinic acid dehydratase

                                     

ⓘ Delta-aminolevulinic acid dehydratase

Delta-aminolevulinic acid dehydratase is an enzyme that in humans is encoded by the ALAD gene. It catalyzes the following reaction:

2 δ-aminolevulinic acid ⇌ {\displaystyle \rightleftharpoons } porphobilinogen + 2 H 2 O

In the ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of Delta-aminolevulinate to form porphobilinogen precursor of heme, cytochromes and other proteins hemodynamic. ALAD catalyzes the second step in the porphyrin and the way of biosynthesis of heme, zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead, a start lead in the blood, which was once considered safe (