ⓘ Carnitine O-acetyltransferase


ⓘ Carnitine O-acetyltransferase

Carnitine O-acetyltransferase also called carnitine acetyltransferase is an enzyme that encoded by the CRAT gene that catalyzes the chemical reaction

acetyl-CoA + carnitine ⇌ {\displaystyle \rightleftharpoons } CoA + acetylcarnitine

where the acetyl group replaces the hydrogen atom in the Central hydroxyl group of carnitine.

Thus, the two substrates of this enzyme acetyl-COA and carnitine, whereas its two products are CoA and o-acetyl-l-carnitine. The reaction is highly reversible and does not depend on the order in which substrates bind.

Different subcellular localization of mRNAs times that as a result of alternative splicing of the Crat gene suggested divergent sequences in the 5 region peroxisomal and mitochondrial Crat cDNAs and the location where intron sequences diverge. Alternative splicing of this gene results in three distinct isoforms, one of which contains the N-terminal mitochondrial transit peptide and was shown to be located in mitochondria.