ⓘ Cofactor of BRCA1

                                     

ⓘ Cofactor of BRCA1

NELF-B is a subunit of negative elongation factor NELF, which also includes NELF-A WHSC2, MIM 606026, either NELF-C or NELF-D TH1L, MIM 605297, and NELF-E RDBP, MIM 154040. NELF acts with DRB sensitivity-inducing factor DSIF, a heterodimer of SPT4 SUPT4H1, MIM 603555 and SPT5 SUPT5H, MIM 602102, to cause transcriptional pausing of RNA polymerase II see MIM 180660. COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.