ⓘ FCN1

                                     

ⓘ FCN1

Ficolin-1, and also commonly termed M-ficolin is a protein that in humans is encoded by the FCN1 gene.

Ficolin family proteins consist of a leader peptide, a short N-terminal segment, after the collagen-like domain and a C-terminal fibrinogen-like domain. The name of ficolin was derived from the last two domains. The collagen-like and fibrinogen-like domains are also found in other proteins, such as tenascins, while the former is also found in complement protein C1q and the collectins, which include mannose-binding lectin and lung surfactant proteins. Ficolins selectively recognize acetylated compounds. M-ficolin is encoded by FCN1 is predominantly expressed in peripheral blood leukocytes, and has been postulated to function as a protein with elastin-binding activity. Several SNPS have been described in the FCN1 gene affects the concentration of serum m-ficolin and ligand binding capacity. M-ficolin levels reflect disease activity and prediction of remission in early rheumatoid arthritis.