ⓘ CDK5RAP2

                                     

ⓘ CDK5RAP2

CDK5 regulatory subunit-associated protein 2 is a protein that in humans is encoded by the CDK5RAP2 gene. It has necessary roles in the formation and stability of microtubules from the centrosome and has been found to be linked to human brain size variation in males. Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined.

CDK5RAP2 is homologous to Drosophila centrosomin protein CNN and paralogous to myomegalin, which in mammals contains the domain Olduvai, the domain involved in the size of human brain evolution.