ⓘ CHMP5

                                     

ⓘ CHMP5

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein CHMP family. These proteins are components of ESCRT-III endosomal sorting complex required for transport III, a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies MVBs. Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.