ⓘ LRRC8A

                                     

ⓘ LRRC8A

Leucine-rich repeat-containing protein 8A is a protein that in humans is encoded by the LRRC8A gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8B, LRRC8C, LRRC8D, and LRRC8E, is a subunit of the heteromer protein volume-regulated anion channel. are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.

And LRRC8A is one of many proteins that may be part of the VRAC is the most important unit of capacity of channel function. However, while we know it is necessary for the function VRAC, other studies have shown that this is not enough for a full circle ordinary activities VRAC. This is where other LRRC8 proteins come in as a different composition of these units affects the range of specificity for VRACs.

In addition to its role in VRACs in LRRC8 family protein is also associated with agammaglobulinemia-5.