ⓘ NOL6

                                     

ⓘ NOL6

Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.

The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes an RNA-associated nucleolar protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that nucleolar localization is RNA dependent. Further studies showed that the protein associated with ribosome biogenesis by interacting with pre-rRNA primary transcripts. Alternative splicing has been observed in the area, and two splice variant encoding different isoforms have been identified.