ⓘ ODF2

                                     

ⓘ ODF2

Outer dense fiber protein 2, also known as cenexin, is a protein that in humans is encoded by the ODF2 gene.

Outer dense fibers are cytoskeletal structures that surround; the axoneme in the middle piece and main parts of the sperm tail. Functions of fiber in maintaining the elastic structure and recoil of the sperm tail, as well as for protecting the tail from shear forces in the epididymis of transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene, however, not all isoforms and variants have been described.