ⓘ Galactose-1-phosphate uridylyltransferase

                                     

ⓘ Galactose-1-phosphate uridylyltransferase

Galactose-1-phosphate uridylyltransferase is an enzyme responsible for converting ingested galactose to glucose.

Galactose-1-phosphate uridylyltransferase Galt catalyzes the second step Leluar of galactose metabolism, namely:

UDP-glucose + galactose 1-phosphate ⇌ {\displaystyle \rightleftharpoons } glucose 1-phosphate + UDP-galactose

The expression of Galt is controlled by the action of the gene FOXO3. The lack of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period, if lactose is not excluded from the diet. The pathophysiology of galactosemia has not been clearly defined.